- Title
- Treatment-induced symptoms, depression and age as predictors of sexual problems in premenopausal women with early breast cancer receiving adjuvant endocrine therapy
- Creator
- Ribi, Karin; Luo, Weixiu; Chia, Stephen; Harvey, Vernon J.; Giobbie-Hurder, Anita; Fleming, Gini F.; Pagani, Olivia; Di Leo, Angelo; Colleoni, Marco; Gelber, Richard D.; Goldhirsch, Aron; Coates, Alan S.; Walley, Barbara A.; Regan, Meredith M.; Bernhard, Jürg; Burstein, Harold J.; Chirgwin, Jacquie; Ansari, Rafat H.; Salim, Muhammed; van der Westhuizen, Andre; Abdi, Ehtesham; Francis, Prudence A.
- Relation
- NHMRC.351161 http://purl.org/au-research/grants/nhmrc/351161 & 510788 http://purl.org/au-research/grants/nhmrc/510788 & 1105058 http://purl.org/au-research/grants/nhmrc/1105058
- Relation
- Breast Cancer Research and Treatment Vol. 181, Issue 2, p. 347-359
- Publisher Link
- http://dx.doi.org/10.1007/s10549-020-05622-5
- Publisher
- Springer
- Resource Type
- journal article
- Date
- 2020
- Description
- Purpose: Sexual dysfunction is an important concern of premenopausal women with early breast cancer. We investigated predictors of sexual problems in two randomized controlled trials. Methods: A subset of patients enrolled in TEXT and SOFT completed global and symptom-specific quality-of-life indicators, CES-Depression and MOS-Sexual Problems measures at baseline, six, 12 and 24 months. Mixed models tested the association of changes in treatment-induced symptoms (baseline to 6 months), depression at 6 months, and age at randomization with changes in sexual problems over 2 years. Results: Sexual problems increased by 6 months and persisted at this level. Overall, patients with more severe worsening of vaginal dryness, sleep disturbances and bone or joint pain at 6 months reported a greater increase in sexual problems at all time-points. Depression scores were significantly associated with sexual problems in the short-term. All other symptoms had a smaller impact on sexual problems. Age was not associated with sexual problems at any time-point. Conclusion: Among several key symptoms, vaginal dryness, sleep disturbance, and bone and joint pain significantly predicted sexual problems during the first 2 years. Early identification of these symptoms may contribute to timely and tailored interventions.
- Subject
- sexual problems; breast cancer; endocrine treatment; treatment-induced symptoms; depression; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1451297
- Identifier
- uon:44148
- Identifier
- ISSN:0167-6806
- Language
- eng
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